2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Potassium Channel

Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110230
    Flupirtine-d4 hydrochloride
    		Activator
    Flupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine. Flupirtine(D 9998) hydrochloride is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
    Flupirtine-d4 hydrochloride
  • HY-170918
    BKCa activator-1
    		Activator
    BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model.
    BKCa activator-1
  • HY-121516
    CM-TPMF
    CM-TPMF is a K(Ca)2 channel modulator with selective activation and inhibition of K(Ca)2.1 subtypes. CM-TPMF can act on K(Ca)2.1 channels as an activator or inhibitor, and its activity is affected by the stereochemical structure. It can be used to study the physiological or pathophysiological effects of K(Ca)2.1 channels.
    CM-TPMF
  • HY-169624
    GPV574
    		Inhibitor
    GPV574 is a derivative of the antiarrhythmic compound propafenone, capable of inhibiting HERG channels (IC50 = 5.04 μM).
    GPV574
  • HY-P5155
    Stromatoxin 1
    		Inhibitor
    Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats.
    Stromatoxin 1
  • HY-116704
    11-Deoxyprostaglandin F2α
    		Modulator
    11-Deoxyprostaglandin F2α is an activator for TREK-2 channels with EC50 of 0.294 μM. 11-Deoxyprostaglandin F2α inhibits the K2P channel TREK-1.
    11-Deoxyprostaglandin F2α
  • HY-15551A
    E-4031 free base
    		Inhibitor
    E-4031 free base is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies.
    E-4031 free base
  • HY-P5795
    GsAF-I
    		Inhibitor
    GsAF-I is a potent Nav and hERG1 channels blocker with IC50s of 0.36, 0.6, 1.28, 0.33, 1.2, 0.04 and 4.8 μM against Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, Nav1.7 and hERG1, respectively.
    GsAF-I
  • HY-15206A
    Glibenclamide potassium
    		Inhibitor
    Glibenclamide (Glyburide) potassium is a potassium salt of Glibenclamide (HY-15206). Glibenclamid potassium exists in anhydrous and hydrate forms, with higher solubility compared to pure Glibenclamide.
    Glibenclamide potassium
  • HY-161624
    Kv7.2 modulator 1
    		Modulator
    Kv7.2 modulator 1 (compound 10) is a Kv7.2 channel modulator and can be used for study of epilepsy.
    Kv7.2 modulator 1
  • HY-78327AS
    (S)-(+)-Modafinic acid-d5
    		Activator
    (S)-(+)-Modafinic acid-d5 is deuterium labeled (S)-(+)-Modafinic acid.
    (S)-(+)-Modafinic acid-d<sub>5</sub>
  • HY-P1274
    ShK-Dap22
    		Inhibitor
    ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively.
    ShK-Dap22
  • HY-172431
    Opakalim
    		Activator
    Opakalim is the activator for potassium channel and exhibits antiepileptic activity.
    Opakalim
  • HY-120375
    LUF7346
    		Inhibitor
    LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC50 of 35.6 ± 3.2 nM.
    LUF7346
  • HY-B1482
    Mesoridazine benzenesulfonate
    		Antagonist
    Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine benzenesulfonate is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells.Mesoridazine benzenesulfonate can be used for the research of schizophrenia, as well as certain other psychiatric disorders.
    Mesoridazine benzenesulfonate
  • HY-P3898
    Tyr-Somatostatin-28
    Tyr-Somatostatin-28 is a somatostatin that adds a Tyrosine amino acid to Somatostatin-28.
    Tyr-Somatostatin-28
  • HY-B0480R
    Brompheniramine (maleate) (Standard)
    		Inhibitor
    Brompheniramine (maleate) (Standard) is the analytical standard of Brompheniramine (maleate). This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.
    Brompheniramine (maleate) (Standard)
  • HY-162555
    BMS-986308
    		Inhibitor
    BMS-986308 is a selective and orally active renal outer medullary potassium (ROMK) channel inhibitor. BMS-986308 is selective for ROMK over hERG. BMS-986308 can be used for heart failure research.
    BMS-986308
  • HY-129088
    HUP30
    		Activator 99.68%
    HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx.
    HUP30
  • HY-163735
    BA6b9
    		Inhibitor
    BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM–PIP2-binding domain with a IC50 value of 8.6 µM (WT SK4). BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the S4–S5 linker. BA6b9 significantly prolongs atrial and atrioventricular effective refractory period (ERP) and reduces atrial fibrillation (AF) induction in rat isolated hearts, which has the potential to be used for the research of arrhythmia .
    BA6b9
Cat. No. Product Name / Synonyms Application Reactivity